SIRT1 plays key role in chronic myeloid leukemia to aid persistence of leukemic stem cells

Patients with chronic myeloid leukemia can be treated with tyrosine kinase inhibitors. While these effective drugs lead to deep remission and prolonged survival, primitive leukemia stem cells resist elimination during the remission and persist as a major barrier to cure. As a result, the majority of patients with chronic myeloid leukemia, or CML, require indefinite inhibitor treatment to prevent disease […]

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AI software reveals the inner workings of short-term memory

Research by neuroscientists at the University of Chicago shows how short-term, working memory uses networks of neurons differently depending on the complexity of the task at hand. The researchers used modern artificial intelligence (AI) techniques to train computational neural networks to solve a range of complex behavioral tasks that required storing information in short term memory. The AI networks were […]

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Body fat distribution linked to higher risk of aggressive prostate cancer

In the first prospective study of directly measured body fat distribution and prostate cancer risk, investigators found that higher levels of abdominal and thigh fat are associated with an increased risk of aggressive prostate cancer. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the findings may lead to a better understanding of the relationship between […]

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Childhood respiratory disorders may be diagnosed with a smartphone

Automated cough analysis technology incorporated in a smartphone app could help to diagnose childhood respiratory disorders, according to a study published in the open access journal Respiratory Research. Researchers at Curtin University and The University of Queensland, Australia, showed that a smartphone app had high accuracy (between 81% and 97%) in diagnosing asthma, croup, pneumonia, lower respiratory tract disease and […]

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Snout dated: Slow-evolving elephant shark offers new insights into human physiology

The mineralocortoid receptor (MR) regulates water and sodium transport throughout cells and tissues, which is critical for controlling blood pressure and so, not surprisingly, the MR is common to all vertebrate animals. Aldosterone, which is a physiological steroid for land vertebrate MRs, evolved in lungfish (forerunners of land vertebrates), suggesting that the evolution of aldosterone was important in the conquest […]

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How early-life challenges affect how children focus, face the day

Adversity early in life tends to affect a child’s executive function skills—their ability to focus, for example, or organize tasks. Experiences such as poverty, residential instability, or parental divorce or substance abuse, also can lead to changes in a child’s brain chemistry, muting the effects of stress hormones. These hormones rise to help us face challenges, stress or to simply […]

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Anti hypertensive drug use was associated with a decreased dementia risk

Various clinical trials indicate what effects can be expected from standardized intervention programs on the basis of existing evidence. Little is known about the way in which such programs can be implemented in actual care practice. However, it may be possible to use data from clinical practice to estimate the potential of drug prescriptions to delay or reduce the development […]

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This Man's Erection Lasted 9 Days After He Was in a Horrible Accident

For most guys, a long-lasting erection might not sound like such a bad thing. But having a hard-on for more than four hours is actually a cause for concern. That was the case for one man, who ended up in the hospital after a moped crash caused him to have a nine-day erection. An article published in Case Reports in Urology in April 2019 states that […]

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Researchers uncovers promising cancer target for liposarcoma

A study conducted by a team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed a close association between liposarcoma (LPS), a type of cancer that develops from fat cells, and the bromodomain and extraterminal (BET) protein family. In the study recently published in prestigious scientific journal, Nature Communications, in […]

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The hidden but preventable epidemic of lung cancer in women

The use of tobacco products, like smoking cigarettes, is the leading preventable cause of cancer worldwide. And lung cancer is still a leading cause of global deaths. But while the number of men dying from lung cancer is starting to fall, recent figures suggest that the number of women dying from the disease around the world is still increasing. Today, […]

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