Many patients with iNPH develop Alzheimer’s disease, too

Up to one in five patients treated for idiopathic normal pressure hydrocephalus, iNPH, also develop Alzheimer’s disease, according to a new study from the University of Eastern Finland and Kuopio University Hospital. The researchers were able to predict the development of Alzheimer’s disease by using the Disease State Index, DSI, that combines patient-specific data from various sources. The results were […]

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New method described for quantifying antisense oligonucleotides in nuclei

A novel method uses subcellular fractionation to quantify label-free antisense oligonucleotides (AONs)- designed to silence targeted genes—that have crossed into the nucleus of a cell, where they can exert their effects. Researchers used this method to correlate nuclear entry of several AON molecules with target gene knockdown and they report their results in Nucleic Acid Therapeutics. Troels Koch and colleagues […]

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New strategy for encapsulating nutrients makes it easier to fortify foods with iron and vitamin A

About 2 billion people around the world suffer from deficiencies of key micronutrients such as iron and vitamin A. Two million children die from these deficiencies every year, and people who don’t get enough of these nutrients can develop blindness, anemia, and cognitive impairments. MIT researchers have now developed a new way to fortify staple foods with these micronutrients by […]

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WHO launches initiative to boost insulin access for diabetics

Credit: CC0 Public Domain The World Health Organization on Wednesday said it had begun an initiative that would cut prices and dramatically increase insulin access for diabetics. The UN health agency voiced alarm ahead of World Diabetes Day Thursday at the soaring prevalence of diabetes in the world, with nearly three times more diabetics today than 35 years ago. There […]

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More hospital days seen with antipsychotic use in Alzheimer disease

(HealthDay)—Alzheimer disease patients who initiate treatment with antipsychotic medications spend more days hospitalized than those who do not initiate antipsychotics, according to a study recently published in the Journal of Post-Acute and Long-Term Care Medicine. Marjaana Koponen, Ph.D., of the Kuopio Research Center of Geriatric Care at the University of Eastern Finland, and colleagues used a nationwide exposure-matched cohort to […]

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Scientists crack rabies virus weaponry

Researchers have found a way to stop the rabies virus shutting down the body’s immune defence against it. In doing so they have solved a key scientific puzzle and have laid the foundation for the development of new anti-rabies vaccines. Rabies kills an estimated 60,000 people a year, most of them in developing countries, overwhelmingly through dog bites. Monash University […]

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Millions unaware of common heart attack symptoms

Millions of Americans don’t know any heart attack symptoms or how to best respond to them, according to a new study that said certain socioeconomic groups are particularly at risk. About 805,000 Americans have a heart attack each year, and about 15% of them die from it. Because early intervention is so critical, health officials have spent decades trying to […]

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The pathway to Parkinson’s takes a surprising twist

In neurodegenerative conditions like Parkinson’s disease, a specific group of neurons start to die one by one, causing movement problems and other symptoms. Scientists have long focused on finding out why these neurons die. Now it turns out, they might not even be dead. Researchers at The Rockefeller University found that affected neurons in Parkinson’s disease can shut down without […]

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Citizen responder CPR and defibrillation programs may improve survival and outcomes from cardiac arrests

Implementing citizen responder programs to answer calls for out-of-hospital cardiac arrests may increase bystander defibrillation in private homes, according to preliminary research to be presented at the American Heart Association’s Resuscitation Science Symposium 2019—November 16-17 in Philadelphia. Most out-of-hospital cardiac arrests occur in residential areas, where automated external defibrillator (AED) devices are rarely available. Researchers in Denmark evaluated whether dispatching […]

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