Taking out the protein garbage becomes more difficult as neurons age

Cells dispose of harmful “trash” through autophagy, a normal and necessary process in which aggregated proteins and dysfunctional structures are handled. If any part of this fails, waste builds up inside cells, eventually killing them. According to a new study from the Perelman School of Medicine at the University of Pennsylvania, as cells age, their ability to shed harmful refuse […]

Read more

CDC assesses burden of eye disorders in adults with diabetes

(HealthDay)—Eye disorders frequently affect adults aged 45 years and older with diagnosed diabetes, and disorders are more common for those with diagnosed diabetes for 10 years or more, according to a July data brief published by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics. Amy E. Cha, Ph.D., M.P.H., from the National Center for Health […]

Read more

Buzz off: breakthrough technique eradicates mosquitoes

Anopheles gambiae mosquito, feeding on blood. Credit: James Gathany, Centers for Disease Control and Prevention A breakthrough technique harnessing two methods to target disease-carrying mosquitoes was able to effectively eradicate buzzing biters in two test sites in China, according to research published on Thursday. The mosquitoes targeted are a type that is particularly difficult to control called Aedes albopictus—more popularly […]

Read more

Perception and working memory are deeply entangled, study finds

Many people have an intuitive, though incorrect, understanding of how the brain works: Our senses perceive objectively factual data, and our higher-level thought processes interpret that data, pull some levers and shape our conclusions and behavior accordingly. But perception and thought are fundamentally linked, according to research published in Nature Human Behavior last week by Dwight Kravitz, an assistant professor […]

Read more

Potassium balance and glaucoma

Retinal ganglion cells (RGCs) make up the optic nerve. When RGCs degenerate due to elevated intraocular pressure caused by glaucoma, vision is lost. Cells surrounding RGCs called Müller glia maintain a healthy ionic environment through a process called potassium siphoning, where Müller glia remove excess potassium ions through potassium channels. These glial potassium channels, such as Kir and K2P, are […]

Read more

Proposed gene therapy for a heart arrhythmia, based on models made from patient cells

Researchers at Boston Children’s Hospital report creating the first human tissue model of an inherited heart arrhythmia, replicating two patients’ abnormal heart rhythms in a dish, and then suppressing the arrhythmia with gene therapy in a mouse model. Their work, published in two papers in the July 30 print issue of the journal Circulation, opens the possibility of developing single-dose […]

Read more

Neuroscientists find brain activity patterns that encode our beliefs

For decades, research has shown that our perception of the world is influenced by our expectations. These expectations, also called “prior beliefs,” help us make sense of what we are perceiving in the present, based on similar past experiences. Consider, for instance, how a shadow on a patient’s X-ray image, easily missed by a less experienced intern, jumps out at […]

Read more

Even in svelte adults, cutting about 300 calories daily protects the heart

New data from a two-year Duke Health trial suggests when it comes to cutting your risk for killer ailments such as diabetes and heart disease, there’s always room for improvement. In adults already at a healthy weight or carrying just a few extra pounds, cutting around 300 calories a day significantly improved already good levels of cholesterol, blood pressure, blood […]

Read more

Annual mammography screenings aren’t the best option for female survivors of some childhood cancers

Female survivors of childhood cancers who have been treated with thoracic radiation, such as survivors of Hodgkin’s lymphoma (HL), have a higher risk of developing breast cancer later in life compared to the general population. To mitigate this risk, current guidelines in Ontario recommend that female HL survivors undergo annual mammography and MRI screenings starting at age 30, the same […]

Read more
1 2 3 43